High-resolution African HLA resource uncoversHLA-DRB1expression effects underlying vaccine response

Change log
Mentzer, Alexander 
Dilthey, Alexander 
Pollard, Martin 
Gurdasani, Deepti 
Karakoc, Emre 

How human genetic variation contributes to vaccine immunogenicity and effectiveness is unclear, particularly in infants from Africa. We undertook genome-wide association analyses of eight vaccine antibody responses in 2,499 infants from three African countries and identified significant associations across the human leukocyte antigen (HLA) locus for five antigens spanning pertussis, diphtheria and hepatitis B vaccines. Using high-resolution HLA typing in 1,706 individuals from 11 African populations we constructed a continental imputation resource to fine-map signals of association across the class II HLA observing genetic variation explaining up to 10% of the observed variance in antibody responses. Using follicular helper T-cell assays, in silico binding, and immune cell eQTL datasets we find evidence of HLA-DRB1 expression correlating with serological response and inferred protection from pertussis following vaccination. This work improves our understanding of molecular mechanisms underlying HLA associations that should support vaccine design and development across Africa with wider global relevance.


High-resolution typing of HLA diversity provides mechanistic insights into differential potency and inferred effectiveness of vaccines across Africa.

Is Part Of
Wellcome Trust (064693, 202802, 203141/Z/16/Z, 217065, 079110, 202802/Z/16/Z, 095778, 106289/Z/14/Z)