Organoid systems to study the human female reproductive tract and pregnancy.
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Peer-reviewed
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Abstract
Both the proper functioning of the female reproductive tract (FRT) and normal placental development are essential for women's health, wellbeing, and pregnancy outcome. The study of the FRT in humans has been challenging due to limitations in the in vitro and in vivo tools available. Recent developments in 3D organoid technology that model the different regions of the FRT include organoids of the ovaries, fallopian tubes, endometrium and cervix, as well as placental trophoblast. These models are opening up new avenues to investigate the normal biology and pathology of the FRT. In this review, we discuss the advances, potential, and limitations of organoid cultures of the human FRT.
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Keywords
Animals, Biomedical Research, Cell Culture Techniques, Three Dimensional, Drug Evaluation, Preclinical, Endometrium, Fallopian Tubes, Female, Genital Diseases, Female, Genital Neoplasms, Female, Humans, Organoids, Ovary, Pregnancy, Reproductive Medicine, Trophoblasts
Journal Title
Cell Death Differ
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Journal ISSN
1350-9047
1476-5403
1476-5403
Volume Title
28
Publisher
Springer Science and Business Media LLC
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Sponsorship
Royal Society (DH160216)
Isaac Newton Trust (Minute 18.40(n))
European Commission Horizon 2020 (H2020) ERC (853546)
Isaac Newton Trust (Minute 18.40(n))
European Commission Horizon 2020 (H2020) ERC (853546)
King Saud University Fellowship (KSU1520)
Royal Society Dorothy Hodgkin Fellowship (DH160216)
Isaac Newton Trust (G100391)
Centre for Trophoblast Research