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Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study.

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cam.depositDate2022-05-27
cam.issuedOnline2022-05-10
dc.contributor.authorNg-Cordell, Elise
dc.contributor.authorKolesnik-Taylor, Anna
dc.contributor.authorO'Brien, Sinéad
dc.contributor.authorAstle, Duncan
dc.contributor.authorScerif, Gaia
dc.contributor.authorBaker, Kate
dc.contributor.orcidNg-Cordell, Elise [0000-0002-4747-8138]
dc.contributor.orcidKolesnik-Taylor, Anna [0000-0002-1395-0377]
dc.contributor.orcidO'Brien, Sinéad [0000-0003-1556-4047]
dc.contributor.orcidAstle, Duncan [0000-0002-7042-5392]
dc.contributor.orcidScerif, Gaia [0000-0002-6371-8875]
dc.contributor.orcidBaker, Kate [0000-0003-2986-0584]
dc.date.accessioned2022-05-27T23:31:00Z
dc.date.available2022-05-27T23:31:00Z
dc.date.issued2022-05-10
dc.date.updated2022-05-27T12:56:09Z
dc.description.abstractDDX3X variants are a common cause of intellectual disability (ID) in females, and have been associated with autism spectrum disorder and emotional-behavioural difficulties. In this study, we compared phenotypic data for 23 females with DDX3X variants, to 23 females with ID and other genetic diagnoses. We found a wide range of adaptive, social and emotional function within the DDX3X group. Autism characteristics did not differ between DDX3X and comparison groups, while levels of anxiety and self-injurious behaviour (SIB) were significantly higher in the DDX3X group. Within the DDX3X group, adaptive function, autism characteristics, anxiety and SIB scores were positively correlated, with evidence for group-specific associations with SIB. Future work is warranted to explore the multilevel mechanisms contributing to social and emotional development in individuals with DDX3X variants.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.84990
dc.identifier.eissn1573-3432
dc.identifier.issn0162-3257
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337581
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.departmentMrc Cognition And Brain Sciences Unit
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnxiety
dc.subjectAutism
dc.subjectDDX3X
dc.subjectIntellectual disability
dc.subjectSelf-injurious behaviour
dc.titleSocial and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study.
dc.typeArticle
dcterms.dateAccepted2022-03-09
prism.endingPage12
prism.publicationDate2022
prism.publicationNameJ Autism Dev Disord
prism.startingPage1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1007/s10803-022-05527-w

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