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The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow.

Published version
Peer-reviewed

Type

Article

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Authors

Roper, Kimberley A 
Berry, Malcolm B 
Ley, Steven V 

Abstract

The application of a monolithic form of triphenylphosphine to the Ramirez gem-dibromoolefination reaction using flow chemistry techniques is reported. A variety of gem-dibromides were synthesised in high purity and excellent yield following only removal of solvent and no further off-line purification. It is also possible to perform the Appel reaction using the same monolith and the relationship between the mechanisms of the two reactions is discussed.

Description

Keywords

Ramirez gem-dibromoolefination reaction, bromination, flow chemistry, solid-supported reagent, triphenylphosphine monolith

Journal Title

Beilstein J Org Chem

Conference Name

Journal ISSN

1860-5397
1860-5397

Volume Title

9

Publisher

Beilstein Institut