Malaria Vaccines: Recent Advances and New Horizons.


Type
Article
Change log
Authors
Draper, Simon J 
Sack, Brandon K 
King, C Richter 
Nielsen, Carolyn M 
Rayner, Julian C 
Abstract

The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success. Here we review the latest vaccine approaches that seek to prevent malaria infection, disease, and transmission and highlight some of the major underlying immunological and molecular mechanisms of protection. The synthesis of rational antigen selection, immunogen design, and immunization strategies to induce quantitatively and qualitatively improved immune effector mechanisms offers promise for achieving sustained high-level protection.

Description
Keywords
Animals, Antigens, Protozoan, Disease Models, Animal, Humans, Immunization, Malaria Vaccines, Malaria, Falciparum, Malaria, Vivax, Plasmodium falciparum, Plasmodium vivax, Sporozoites, Vaccines, Subunit
Journal Title
Cell Host Microbe
Conference Name
Journal ISSN
1931-3128
1934-6069
Volume Title
24
Publisher
Elsevier BV