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Gene exchange drives the ecological success of a multi-host bacterial pathogen.

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cam.issuedOnline2018-07-23
dc.contributor.authorRichardson, Emily J
dc.contributor.authorBacigalupe, Rodrigo
dc.contributor.authorHarrison, Ewan M
dc.contributor.authorWeinert, Lucy A
dc.contributor.authorLycett, Samantha
dc.contributor.authorVrieling, Manouk
dc.contributor.authorRobb, Kirsty
dc.contributor.authorHoskisson, Paul A
dc.contributor.authorHolden, Matthew TG
dc.contributor.authorFeil, Edward J
dc.contributor.authorPaterson, Gavin K
dc.contributor.authorTong, Steven YC
dc.contributor.authorShittu, Adebayo
dc.contributor.authorvan Wamel, Willem
dc.contributor.authorAanensen, David M
dc.contributor.authorParkhill, Julian
dc.contributor.authorPeacock, Sharon J
dc.contributor.authorCorander, Jukka
dc.contributor.authorHolmes, Mark
dc.contributor.authorFitzgerald, J Ross
dc.contributor.orcidLycett, Samantha [0000-0003-3159-596X]
dc.contributor.orcidHoskisson, Paul A [0000-0003-4332-1640]
dc.contributor.orcidHolden, Matthew TG [0000-0002-4958-2166]
dc.contributor.orcidParkhill, Julian [0000-0002-7069-5958]
dc.contributor.orcidFitzgerald, J Ross [0000-0002-9233-8468]
dc.date.accessioned2018-09-29T06:09:17Z
dc.date.available2018-09-29T06:09:17Z
dc.date.issued2018-09
dc.description.abstractThe capacity for some pathogens to jump into different host-species populations is a major threat to public health and food security. Staphylococcus aureus is a multi-host bacterial pathogen responsible for important human and livestock diseases. Here, using a population-genomic approach, we identify humans as a major hub for ancient and recent S. aureus host-switching events linked to the emergence of endemic livestock strains, and cows as the main animal reservoir for the emergence of human epidemic clones. Such host-species transitions are associated with horizontal acquisition of genetic elements from host-specific gene pools conferring traits required for survival in the new host-niche. Importantly, genes associated with antimicrobial resistance are unevenly distributed among human and animal hosts, reflecting distinct antibiotic usage practices in medicine and agriculture. In addition to gene acquisition, genetic diversification has occurred in pathways associated with nutrient acquisition, implying metabolic remodelling after a host switch in response to distinct nutrient availability. For example, S. aureus from dairy cattle exhibit enhanced utilization of lactose-a major source of carbohydrate in bovine milk. Overall, our findings highlight the influence of human activities on the multi-host ecology of a major bacterial pathogen, underpinned by horizontal gene transfer and core genome diversification.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.30309
dc.identifier.eissn2397-334X
dc.identifier.issn2397-334X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282946
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41559-018-0617-0
dc.subjectAnimals
dc.subjectCattle
dc.subjectEvolution, Molecular
dc.subjectGene Transfer, Horizontal
dc.subjectGenes, Bacterial
dc.subjectGenome, Bacterial
dc.subjectGenome-Wide Association Study
dc.subjectHost-Pathogen Interactions
dc.subjectHumans
dc.subjectLivestock
dc.subjectPhylogeny
dc.subjectPseudogenes
dc.subjectStaphylococcal Infections
dc.subjectStaphylococcus aureus
dc.titleGene exchange drives the ecological success of a multi-host bacterial pathogen.
dc.typeArticle
dcterms.dateAccepted2018-06-25
prism.endingPage1478
prism.issueIdentifier9
prism.publicationDate2018
prism.publicationNameNat Ecol Evol
prism.startingPage1468
prism.volume2
pubs.funder-project-idWellcome Trust (098600/Z/12/Z)
pubs.funder-project-idRoyal Society (DH140195)
pubs.funder-project-idWellcome Trust (109385/Z/15/Z)
pubs.funder-project-idMedical Research Council (G1001787)
pubs.funder-project-idMedical Research Council (G1000803)
pubs.funder-project-idMedical Research Council (MR/P007201/1)
pubs.funder-project-idNational Institute for Health and Care Research (HICF-T5-342)
pubs.funder-project-idMedical Research Council (G1000803/1)
pubs.funder-project-idMedical Research Council (G1001787/1)
rioxxterms.licenseref.startdate2018-09
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1038/s41559-018-0617-0

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