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Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie?

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cam.issuedOnline2018-07-31
dc.contributor.authorThompson, Mareike K
dc.contributor.authorPoortmans, Philip
dc.contributor.authorChalmers, Anthony J
dc.contributor.authorFaivre-Finn, Corinne
dc.contributor.authorHall, Emma
dc.contributor.authorHuddart, Robert A
dc.contributor.authorLievens, Yolande
dc.contributor.authorSebag-Montefiore, David
dc.contributor.authorColes, Charlotte E
dc.contributor.orcidColes, Charlotte [0000-0003-4473-8552]
dc.date.accessioned2018-10-22T06:53:55Z
dc.date.available2018-10-22T06:53:55Z
dc.date.issued2018-08
dc.description.abstractAs we mark 150 years since the birth of Marie Curie, we reflect on the global advances made in radiation oncology and the current status of radiation therapy (RT) research. Large-scale international RT clinical trials have been fundamental in driving evidence-based change and have served to improve cancer management and to reduce side effects. Radiation therapy trials have also improved practice by increasing quality assurance and consistency in treatment protocols across multiple centres. This review summarises some of the key RT practice-changing clinical trials over the last two decades, in four common cancer sites for which RT is a crucial component of curative treatment: breast, lung, urological and lower gastro-intestinal cancer. We highlight the global inequality in access to RT, and the work of international organisations, such as the International Atomic Energy Agency (IAEA), the European SocieTy for Radiotherapy and Oncology (ESTRO), and the United Kingdom National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad), that aim to improve access to RT and facilitate radiation research. We discuss some emerging RT technologies including proton beam therapy and magnetic resonance linear accelerators and predict likely future directions in clinical RT research.
dc.description.sponsorshipNIHR Cambridge BRC
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.31556
dc.identifier.eissn1532-1827
dc.identifier.issn0007-0920
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284188
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41416-018-0201-z
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBreast Neoplasms
dc.subjectClinical Trials as Topic
dc.subjectEurope
dc.subjectFemale
dc.subjectGastrointestinal Neoplasms
dc.subjectHealth Services Accessibility
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectMale
dc.subjectNeoplasms
dc.subjectPractice Guidelines as Topic
dc.subjectUrologic Neoplasms
dc.titlePractice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie?
dc.typeArticle
dcterms.dateAccepted2018-06-22
prism.endingPage407
prism.issueIdentifier4
prism.publicationDate2018
prism.publicationNameBr J Cancer
prism.startingPage389
prism.volume119
rioxxterms.licenseref.startdate2018-08
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41416-018-0201-z

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