Repository logo
 

Post-haemorrhagic hydrocephalus is associated with poorer surgical and neurodevelopmental sequelae than other causes of infant hydrocephalus

Simple item page
dc.contributor.authorMohamed, Malak
dc.contributor.authorMediratta, Saniya
dc.contributor.authorChari, Aswin
dc.contributor.authorda Costa, Cristine Sortica
dc.contributor.authorJames, Greg
dc.contributor.authorDawes, William
dc.contributor.authorAquilina, Kristian
dc.contributor.orcidMohamed, Malak [0000-0002-7248-6420]
dc.date.accessioned2021-11-09T16:34:13Z
dc.date.available2021-11-09T16:34:13Z
dc.date.issued2021-06-19
dc.date.submitted2021-04-04
dc.date.updated2021-11-09T16:34:12Z
dc.description.abstractAbstract: Purpose: This retrospective cohort study aimed to investigate the surgical and neurodevelopmental outcomes (NDO) of infant hydrocephalus. We also sought to determine whether these outcomes are disproportionately poorer in post-haemorrhagic hydrocephalus (PHH) compared to other causes of infant hydrocephalus. Methods: A review of all infants with hydrocephalus who had ventriculoperitoneal (VP) shunts inserted at Great Ormond Street Hospital (GOSH) from 2008 to 2018 was performed. Demographic, surgical, neurodevelopmental, and other clinical data extracted from electronic patient notes were analysed by aetiology. Shunt survival, NDO, cerebral palsy (CP), epilepsy, speech delay, education, behavioural disorders, endocrine dysfunction, and mortality were evaluated. Results: A total of 323 infants with median gestational age of 37.0 (23.29–42.14) weeks and birthweight of 2640 g (525–4684 g) were evaluated. PHH was the most common aetiology (31.9%) and was associated with significantly higher 5-year shunt revision rates, revisions beyond a year, and median number of revisions than congenital or “other” hydrocephalus (all p < 0.02). Cox regression demonstrated poorest shunt survival in PHH, related to gestational age at birth and corrected age at shunt insertion. PHH also had the highest rate of severe disabilities, increasing with age to 65.0% at 10 years, as well as the highest CP rate; only genetic hydrocephalus had significantly higher endocrine dysfunction (p = 0.01) and mortality rates (p = 0.04). Conclusions: Infants with PHH have poorer surgical and NDO compared to all other aetiologies, except genetic hydrocephalus. Research into measures of reducing neurodisability following PHH is urgently required. Long-term follow-up is essential to optimise support and outcomes.
dc.identifier.doi10.17863/CAM.77941
dc.identifier.eissn1433-0350
dc.identifier.issn0256-7040
dc.identifier.others00381-021-05226-4
dc.identifier.other5226
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330498
dc.languageen
dc.publisherSpringer Berlin Heidelberg
dc.subjectAnnual Issue Paper
dc.subjectIntraventricular haemorrhage
dc.subjectHydrocephalus
dc.subjectNeonates
dc.subjectVentriculoperitoneal shunts
dc.subjectNeurodevelopmental outcome
dc.titlePost-haemorrhagic hydrocephalus is associated with poorer surgical and neurodevelopmental sequelae than other causes of infant hydrocephalus
dc.typeArticle
dcterms.dateAccepted2021-05-21
prism.endingPage3396
prism.issueIdentifier11
prism.publicationNameChild's Nervous System
prism.startingPage3385
prism.volume37
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1007/s00381-021-05226-4

Files

Original bundle
Now showing 1 - 3 of 3
No Thumbnail Available
Name:
additional-files.zip
Size:
74.91 KB
Format:
ZIP file
Description:
Supporting information
Licence
http://creativecommons.org/licenses/by/4.0/
Download
Thumbnail Image
Name:
381_2021_Article_5226.pdf
Size:
1.01 MB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
http://creativecommons.org/licenses/by/4.0/
Download
No Thumbnail Available
Name:
381_2021_Article_5226_nlm.xml
Size:
115.22 KB
Format:
Extensible Markup Language
Description:
Bibliographic metadata
Licence
http://creativecommons.org/licenses/by/4.0/
Download

Collections

Jisc Publications Router