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Anticipatory prescribing in community end-of-life care: systematic review and narrative synthesis of the evidence since 2017.

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Antunes, Bárbara Costa Pereira  ORCID logo
Etkind, Simon 


BACKGROUND: The anticipatory prescribing of injectable medications is recommended practice in controlling distressing symptoms in the last days of life. A 2017 systematic review found practice and guidance was based on inadequate evidence. Since then, there has been considerable additional research, warranting a new review. AIM: To review the evidence published since 2017 concerning anticipatory prescribing of injectable medications for adults at the end-of-life in the community, to inform practice and guidance. DESIGN: Systematic review and narrative synthesis. METHODS: Nine literature databases were searched from May 2017 to March 2022, alongside reference, citation and journal hand-searches. Gough's Weight of Evidence framework was used to appraise included studies. RESULTS: Twenty-eight papers were included in the synthesis. Evidence published since 2017 shows that standardised prescribing of four medications for anticipated symptoms is commonplace in the UK; evidence of practices in other countries is limited. There is limited data on how often medications are administered in the community. Prescriptions are 'accepted' by family caregivers despite inadequate explanations and they generally appreciate having access to medications. Robust evidence of the clinical and cost-effectiveness of anticipatory prescribing remains absent. CONCLUSION: The evidence underpinning anticipatory prescribing practice and policy remains based primarily on healthcare professionals' perceptions that the intervention is reassuring, provides effective, timely symptom relief in the community and prevents crisis hospital admissions. There is still inadequate evidence regarding optimal medications and dose ranges, and the effectiveness of these prescriptions. Patient and family caregiver experiences of anticipatory prescriptions warrant urgent investigation. PROSPERO REGISTRATION: CRD42016052108.



clinical decisions, drug administration, home care, pain, symptoms and symptom management, terminal care

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BMJ Support Palliat Care

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National Institute for Health Research (NIHR) (SPCR-146)
National Institute for Health Research (NIHR) (via University of Oxford) (Capacity Building Award 9)
BB received funding by the National Institute for Health Research (NIHR) School for Primary Care Research [SPCR-146]. This work was supported by the Wellcome Trust [225577/Z/22/Z]. SI is funded as a Health Education England Clinical Lecturer. SH is jointly funded by The Dunhill Medical Trust and British Geriatrics Society [JBGS20\5]. BA and SB are supported by the NIHR Applied Research Collaboration East of England (NIHR ARC EoE) at Cambridge and Peterborough NHS Foundation Trust.