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Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients.

Published version
Peer-reviewed

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Authors

Barrera-Conde, Marta  ORCID logo  https://orcid.org/0000-0002-0106-0000
Ausin, Karina 
Lachén-Montes, Mercedes 
Fernández-Irigoyen, Joaquín  ORCID logo  https://orcid.org/0000-0001-5072-4099
Galindo, Liliana 

Abstract

A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory neuroepithelium (ON) cells express neural features and offer a unique advantage to study biomarkers of psychiatric diseases. The aim of our study was to find exclusively deregulated proteins in ON cells of SCZ patients with and without a history of cannabis use. Thus, we compared the proteomic profiles of SCZ non-cannabis users (SCZ/nc) and SCZ cannabis users (SCZ/c) with control subjects non-cannabis users (C/nc) and control cannabis users (C/c). The results revealed that the main cascades affected in SCZ/nc were cell cycle, DNA replication, signal transduction and protein localization. Conversely, cannabis use in SCZ patients induced specific alterations in metabolism of RNA and metabolism of proteins. The levels of targeted proteins in each population were then correlated with cognitive performance and clinical scores. In SCZ/c, the expression levels of 2 proteins involved in the metabolism of RNA (MTREX and ZNF326) correlated with several cognitive markers and clinical signs. Moreover, use duration of cannabis negatively correlated with ZNF326 expression. These findings indicate that RNA-related proteins might be relevant to understand the influence of cannabis use on SCZ.

Description

Keywords

MTREX, RNA, ZNF326, cannabis, metabolism, olfactory neuroepithelium, proteomics, schizophrenia

Journal Title

J Pers Med

Conference Name

Journal ISSN

2075-4426
2075-4426

Volume Title

11

Publisher

MDPI AG