Repository logo
 

Deconstructing and reconstructing behaviour relevant to mental health disorders: The benefits of a psychological approach, with a focus on addiction.

Simple item page
cam.depositDate2021-12-29
cam.issuedOnline2021-12-24
cam.orpheus.success2022-01-04 - Embargo set during processing via Fast-track
dc.contributor.authorRutherford, Lydia G
dc.contributor.authorMilton, Amy L
dc.contributor.orcidMilton, Amy [0000-0003-0175-9417]
dc.date.accessioned2022-01-05T00:31:44Z
dc.date.available2022-01-05T00:31:44Z
dc.date.issued2022-02
dc.date.updated2021-12-29T18:36:51Z
dc.description.abstractRUTHERFORD, L.G. and Milton, A.L. Deconstructing and reconstructing behaviour relevant to mental health disorders: The benefits of a psychological approach, with a focus on addiction. NEUROSCI BIOBEHAV REV XX(X)XXX-XXX, 2021. - Current treatments for mental health disorders are successful only for some patients, and there is an unmet clinical need for new treatment development. One challenge for treatment development has been how best to model complex human conditions in animals, where mechanisms can be more readily studied with a range of neuroscientific techniques. We suggest that an approach to modelling based on associative animal learning theory provides a suitable framework for deconstructing complex mental health disorders such that they can be studied in animals. These individual simple models can subsequently be used in combination to 'reconstruct' a more complex model of the mental health disorder of interest. Using examples primarily from the field of drug addiction, we explore the 'psychological approach' and suggest that in addition to facilitating translation and backtranslation of tasks between animal models and patients, this approach is also highly concordant with the concept of triangulation.
dc.description.sponsorshipThis work was supported by a UK Medical Research Council grant to ALM (MR/N02530X/1).
dc.identifier.doi10.17863/CAM.79404
dc.identifier.eissn1873-7528
dc.identifier.issn0149-7634
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331955
dc.language.isoeng
dc.publisherElsevier BV
dc.publisher.departmentDepartment of Psychology
dc.publisher.urlhttp://dx.doi.org/10.1016/j.neubiorev.2021.104514
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAssociative learning
dc.subjectBehaviour
dc.subjectMental health
dc.subjectPsychology
dc.subjectTriangulation
dc.subjectAnimals
dc.subjectBehavior, Addictive
dc.subjectHumans
dc.subjectMental Disorders
dc.subjectMental Health
dc.titleDeconstructing and reconstructing behaviour relevant to mental health disorders: The benefits of a psychological approach, with a focus on addiction.
dc.typeArticle
dcterms.dateAccepted2021-11-16
prism.endingPage104514
prism.number104514
prism.publicationDate2021
prism.publicationNameNeurosci Biobehav Rev
prism.startingPage104514
pubs.funder-project-idMedical Research Council (MR/N02530X/1)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/j.neubiorev.2021.104514

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Rutherford & Milton AAM.pdf
Size:
263.39 KB
Format:
Adobe Portable Document Format
Description:
Accepted version
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0/
Download

Collections

Cambridge University Research Outputs