Repository logo

The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI): Incidence and First-Episode Case–Control Programme

Published version

Change log


Gayer-Anderson, Charlotte  ORCID logo
Jongsma, Hannah E. 
Di Forti, Marta 
Quattrone, Diego 
Velthorst, Eva 


Abstract: Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case–control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions: This resource constitutes the largest and most extensive incidence and case–control study of psychosis ever conducted.


Funder: FP7 Ideas: European Research Council; doi:; Grant(s): HEALTH-F2-2010-241909


Study Protocols and Samples, Case–control, Environment–environment interactions, EU-GEI, First-episode psychosis, Gene–environment interactions, Incidence

Journal Title

Social Psychiatry and Psychiatric Epidemiology

Conference Name

Journal ISSN


Volume Title



Springer Berlin Heidelberg
São Paulo Research Foundation (2012/0417-0)