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Asymmetric parameter enhancement in the split-ring cavity array for virus-like particle sensing.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Jin, Xiao 
Xue, Lu 
Ye, Shengwei 
Cheng, Weiqing 
Hou, Jamie Jiangmin  ORCID logo  https://orcid.org/0000-0001-5836-1827

Abstract

Quantitative detection of virus-like particles under a low concentration is of vital importance for early infection diagnosis and water pollution analysis. In this paper, a novel virus detection method is proposed using indirect polarization parametric imaging method combined with a plasmonic split-ring nanocavity array coated with an Au film and a quantitative algorithm is implemented based on the extended Laplace operator. The attachment of viruses to the split-ring cavity breaks the structural symmetry, and such asymmetry can be enhanced by depositing a thin gold film on the sample, which allows an asymmetrical plasmon mode with a large shift of resonance peak generated under transverse polarization. Correspondingly, the far-field scattering state distribution encoded by the attached virus exhibits a specific asymmetric pattern that is highly correlated to the structural feature of the virus. By utilizing the parametric image sinδ to collect information on the spatial photon state distribution and far-field asymmetry with a sub-wavelength resolution, the appearance of viruses can be detected. To further reduce the background noise and enhance the asymmetric signals, an extended Laplace operator method which divides the detection area into topological units and then calculates the asymmetric parameter is applied, enabling easier determination of virus appearance. Experimental results show that the developed method can provide a detection limit as low as 56 vp/150µL on a large scale, which has great potential in early virus screening and other applications.

Description

Keywords

40 Engineering, 4009 Electronics, Sensors and Digital Hardware, Infection

Journal Title

Biomed Opt Express

Conference Name

Journal ISSN

2156-7085
2156-7085

Volume Title

14

Publisher

Optica Publishing Group