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Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Mikhaylov, Roman 
Wu, Fangda 
Wang, Hanlin 
Clayton, Aled 
Sun, Chao 

Abstract

Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. In this paper, we develop a novel and simple technology to fabricate a surface acoustic wave (SAW)-based acoustofluidic device by clamping electrodes made using a printed circuit board (PCB) with a piezoelectric substrate. The PCB-based SAW (PCB-SAW) device is systematically characterised and benchmarked with a SAW device made using the conventional photolithography process with the same specifications. Microparticle manipulations such as streaming in droplets and patterning in microchannels were demonstrated in the PCB-SAW device. In addition, the PCB-SAW device was applied as an acoustic tweezer to pattern lung cancer cells to form three or four traces inside the microchannel in a controllable manner. Cell viability of ∼97% was achieved after acoustic manipulation using the PCB-SAW device, which proved its ability as a suitable tool for acoustophoretic applications.

Description

Keywords

Acoustics, Electrodes, Sound

Journal Title

Lab Chip

Conference Name

Journal ISSN

1473-0197
1473-0189

Volume Title

20

Publisher

Royal Society of Chemistry (RSC)

Rights

All rights reserved
Sponsorship
The authors would gratefully acknowledge the financial support from EPSRC (EP/P002803/1, EP/P018998/1), EPSRC IAA, Welcome Trust, Global Challenges Research Fund (GCRF), the Royal Society (IEC\NSFC\170142, IE161019), and the Natural Science Foundation of China (NSFC) (Grant No. 51811530310).