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Associations of dietary patterns with brain health from behavioral, neuroimaging, biochemical and genetic analyses

Published version
Peer-reviewed

Repository DOI


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Authors

Zhang, Ruohan 
Shen, Chun 
Sahakian, Barbara J  ORCID logo  https://orcid.org/0000-0001-7352-1745
Li, Zeyu 

Abstract

jats:titleAbstract</jats:title>jats:pFood preferences significantly influence dietary choices, yet understanding natural dietary patterns in populations remains limited. Here we identifiy four dietary subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ (subtype 2), ‘high protein and low fiber’ (subtype 3) and ‘balanced’ (subtype 4). These subtypes varied in diverse brain health domains. The individuals with a balanced diet demonstrated better mental health and superior cognitive functions relative to other three subtypes. Compared with subtype 4, subtype 3 displayed lower gray matter volumes in regions such as the postcentral gyrus, while subtype 2 showed higher volumes in thalamus and precuneus. Genome-wide association analyses identified 16 genes different between subtype 3 and subtype 4, enriched in biological processes related to mental health and cognition. These findings provide new insights into naturally developed dietary patterns, highlighting the importance of a balanced diet for brain health.</jats:p>

Description

Acknowledgements: W.C. was supported by grants from the Shanghai Rising-Star Program (21QA1408700), the National Natural Sciences Foundation of China (82071997) and the National Key Research and Development Program of China (grant no. 2023YFC3605400). J.F. was supported by the National Key R&D Program of China (2018YFC1312900 and 2019YFA0709502), the Shanghai Municipal Science and Technology Major Project (2018SHZDZX01), the ZJ Lab, Shanghai Center for Brain Science and Brain-Inspired Technology and the 111 Project (B18015). The funders played no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.


Funder: Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) (no. 2019YFA0709502) The Shanghai Municipal Science and Technology Major Project (no. 2018SHZDZX01) The ZJ Lab, Shanghai Center for Brain Science and Brain-Inspired Technology and the 111 Project (no. B18015)


Funder: The Shanghai Rising-Star Program (no. 21QA1408700). National Key Research and Development Program of China (grant no. 2023YFC3605400).

Keywords

32 Biomedical and Clinical Sciences, 3210 Nutrition and Dietetics, 52 Psychology, Behavioral and Social Science, Genetics, Human Genome, Neurosciences, Nutrition, 1 Underpinning research, 1.1 Normal biological development and functioning, Neurological, Mental health, 3 Good Health and Well Being

Journal Title

Nature Mental Health

Conference Name

Journal ISSN

2731-6076
2731-6076

Volume Title

2

Publisher

Springer Science and Business Media LLC
Sponsorship
Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) (2018YFC1312900)
National Natural Science Foundation of China (National Science Foundation of China) (82071997)