Caught in the antiviral crossfire: Ganciclovir-associated mutagenesis in HSC transplant recipients.

Caught in the antiviral crossfire: Ganciclovir-associated mutagenesis in HSC transplant recipients.

Published version

Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/346019

Repository DOI

https://doi.org/10.17863/CAM.93441

Files

Published version (361.85 KB)

Type

Authors

Spencer Chapman, Michael

https://orcid.org/0000-0002-5320-8193

Nangalia, Jyoti

https://orcid.org/0000-0001-7122-4608

Abstract

In this issue of Cell Stem Cell, de Kanter et al. (2021) show that most allogeneic hematopoietic stem cells do not acquire additional somatic mutations following transplantation. However, they observe somatic mutagenesis associated with the antiviral drug ganciclovir and find plausible evidence that it may contribute to some post-transplant malignancies.

Keywords

Antiviral Agents, Cytomegalovirus Infections, Ganciclovir, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, Mutagenesis, Transplant Recipients

Journal Title

Cell Stem Cell

Journal ISSN

1934-5909
1875-9777

Volume Title

28

Publisher

Elsevier

Publisher DOI

https://doi.org/10.1016/j.stem.2021.09.011

Rights and licensing

Publisher's own licence

Sponsorship

Medical Research Council (MC_PC_17230)
Cancer Research UK (23917)

Collections

University of Cambridge Research Outputs (Articles and Conferences)