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Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth.

Published version
Peer-reviewed

Type

Article

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Authors

van Diepen, Janna A 
Chichlowski, Maciej 
Vervoort, Jacques 

Abstract

Butyrate in human milk (HM) has been suggested to reduce excessive weight and adipo-sity gains during infancy. However, HM butyrate's origins, determinants, and its influencing mechanism on weight gain are not completely understood. These were studied in the prospective longitudinal Cambridge Baby Growth and Breastfeeding Study (CBGS-BF), in which infants (n = 59) were exclusively breastfed for at least 6 weeks. Infant growth (birth, 2 weeks, 6 weeks, 3 months, 6 months, and 12 months) and HM butyrate concentrations (2 weeks, 6 weeks, 3 months, and 6 months) were measured. At age 6 weeks, HM intake volume was measured by deuterium-labelled water technique and HM microbiota by 16S sequencing. Cross-sectionally at 6 weeks, HM butyrate was associated with HM microbiota composition (p = 0.036) although no association with the abundance of typical butyrate producers was detected. In longitudinal analyses across all time points, HM butyrate concentrations were overall negatively associated with infant weight and adiposity, and associations were stronger at younger infant ages. HM butyrate concentration was also inversely correlated with HM intake volume, supporting a possible mechanism whereby butyrate might reduce infant growth via appetite regulation and modulation of HM intake.

Description

Keywords

butyrate intake, human milk butyrate, human milk intake volume, human milk microbiota, infant adiposity, infant growth, infant weight gain, Female, Humans, Infant, Milk, Human, Butyrates, Prospective Studies, Breast Feeding, Weight Gain, Microbiota

Journal Title

Nutrients

Conference Name

Journal ISSN

2072-6643
2072-6643

Volume Title

15

Publisher

MDPI AG
Sponsorship
Medical Research Council (MC_UU_12015/2)
MRC (MC_UU_00006/2)