Repository logo
 

Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism

Published version
Peer-reviewed

Repository DOI


Type

Article

Change log

Authors

Iglesias, Maria Jesus 
Sanchez-Rivera, Laura 
Ibrahim-Kosta, Manal 

Abstract

jats:titleAbstract</jats:title>jats:pVenous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement Factor H Related 5 protein (CFHR5), a regulator of the alternative pathway of complement activation, is a VTE-associated plasma biomarker. In plasma, higher CFHR5 levels are associated with increased thrombin generation potential and recombinant CFHR5 enhanced platelet activation in vitro. GWAS analysis of ~52,000 participants identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization do not demonstrate causality between CFHR5 and VTE. Our results indicate an important role for the regulation of the alternative pathway of complement activation in VTE and that CFHR5 represents a potential diagnostic and/or risk predictive plasma biomarker.</jats:p>

Description

Keywords

Journal Title

Nature Communications

Conference Name

Journal ISSN

2041-1723

Volume Title

14

Publisher

Springer Science and Business Media LLC