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Intratumoral Heterogeneity: Tools to Understand and Exploit Clone Wars in AML.

Accepted version
Peer-reviewed

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Type

Article

Change log

Authors

Giotopoulos, George  ORCID logo  https://orcid.org/0000-0003-1390-6592
Huntly, Brian JP 

Abstract

In this issue of Cancer Cell, de Boer et al. refine a set of acute myeloid leukemia (AML)-enriched plasma membrane markers that can be used to identify, prospectively isolate, and longitudinally track leukemic subclones within individual AML patients, correlating immunophenotypic profiles with specific mutational signatures, transcription, functional behavior, and therapeutic outcomes.

Description

Keywords

Cells, Cultured, Humans, Leukemia, Myeloid, Acute, Mutation, Prospective Studies

Journal Title

Cancer Cell

Conference Name

Journal ISSN

1535-6108
1878-3686

Volume Title

34

Publisher

Elsevier BV
Sponsorship
Medical Research Council (MC_PC_12009)
Medical Research Council (MR/M010392/1)
Medical Research Council (MR/R009708/1)
Cancer Research UK (25508)