Intratumoral Heterogeneity: Tools to Understand and Exploit Clone Wars in AML.


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Type
Article
Change log
Authors
Giotopoulos, George  ORCID logo  https://orcid.org/0000-0003-1390-6592
Huntly, Brian JP 
Abstract

In this issue of Cancer Cell, de Boer et al. refine a set of acute myeloid leukemia (AML)-enriched plasma membrane markers that can be used to identify, prospectively isolate, and longitudinally track leukemic subclones within individual AML patients, correlating immunophenotypic profiles with specific mutational signatures, transcription, functional behavior, and therapeutic outcomes.

Description
Keywords
Cells, Cultured, Humans, Leukemia, Myeloid, Acute, Mutation, Prospective Studies
Journal Title
Cancer Cell
Conference Name
Journal ISSN
1535-6108
1878-3686
Volume Title
34
Publisher
Elsevier BV
Sponsorship
Medical Research Council (MC_PC_12009)
Medical Research Council (MR/M010392/1)
Medical Research Council (MR/R009708/1)