Arming the troops: Post-translational modification of extracellular bacterial proteins.

Protein secretion is almost universally employed by bacteria. Some proteins are retained on the cell surface, whereas others are released into the extracellular milieu, often playing a key role in virulence. In this review, we discuss the diverse types and potential functions of post-translational modifications (PTMs) occurring to extracellular bacterial proteins.

Keywords

Post-translational modification, acetylation, bacterial pathogens, bacterial virulence factors, glycosylation, lipidation, methylation, protein secretion, proteomics, Bacteria, Bacterial Proteins, Protein Processing, Post-Translational, Proteomics, Virulence

Journal Title

Sci Prog

Journal ISSN

0036-8504
2047-7163

Volume Title

103

Publisher

SAGE Publications

Publisher DOI

https://doi.org/10.1177/0036850420964317

Rights and licensing

Sponsorship

Evelyn Trust (17/51)
BBSRC (1646528)

SF was supported by a studentship from the BBSRC DTP and by funding from the Evelyn Trust (Cambridge). Work in the MW laboratory is supported by the Cystic Fibrosis Trust, The British Lung Foundation and the BBSRC.

Collections

University of Cambridge Research Outputs (Articles and Conferences)