Metaplastic Cdx2-depleted cells can be very disruptive neighbors.

In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring "normal" Cdx2-positive cells.

Keywords

Animals, CDX2 Transcription Factor, Carcinogenesis, Genes, Homeobox, Homeodomain Proteins, Mice, Mice, Transgenic

Journal Title

J Exp Med

Journal ISSN

0022-1007
1540-9538

Volume Title

215

Publisher

Rockefeller University Press

Publisher DOI

https://doi.org/10.1084/jem.20180215

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Except where otherwised noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International

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Cancer Research UK (CB4230)
Cancer Research UK (C14303/A17197)
Cancer Research UK (17044)

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Scholarly Works - Cancer Research UK Cambridge Institute

Metaplastic Cdx2-depleted cells can be very disruptive neighbors.

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Peer-reviewed

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