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Local translation in neurons: visualization and function.

Accepted version
Peer-reviewed

Type

Article

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Authors

Holt, Christine E 
Martin, Kelsey C 

Abstract

Neurons are among the most compartmentalized and interactive of all cell types. Like all cells, neurons use proteins as the main sensors and effectors. The modification of the proteome in axons and dendrites is used to guide the formation of synaptic connections and to store information. In this Review, we discuss the data indicating that an important source of protein for dendrites, axons and their associated elements is provided by the local synthesis of proteins. We review the data indicating the presence of the machinery required for protein synthesis, the direct visualization and demonstration of protein synthesis, and the established functional roles for local translation for many different neuronal functions. Finally, we consider the open questions and future directions in this field.

Description

Keywords

Animals, Humans, Microscopy, Neurons, Protein Biosynthesis, Protein Processing, Post-Translational, RNA, Messenger, Ribosomes

Journal Title

Nat Struct Mol Biol

Conference Name

Journal ISSN

1545-9993
1545-9985

Volume Title

26

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (203249/Z/16/Z)
European Research Council (322817)