Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization.


Type
Article
Change log
Abstract

Inflammation contributes to atherosclerosis and coronary artery disease (CAD). In order to help identify therapeutic targets, it is important to ascertain whether biomarkers associated with CAD risk are causal. In a recent meta-analysis of clinical trials, neutrophil-to lymphocyte ratio (NLR) was associated with increased cardiovascular risk 1 . We investigate a potential causal nature of this relationship by performing Mendelian randomization (MR) analyses

Description
Keywords
cardiovascular diseases, causality, inflammation, linear models, neutrophils, Coronary Artery Disease, Genome-Wide Association Study, Humans, Lymphocytes, Mendelian Randomization Analysis, Neutrophils
Journal Title
Circ Genom Precis Med
Conference Name
Journal ISSN
2574-8300
2574-8300
Volume Title
15
Publisher
Ovid Technologies (Wolters Kluwer Health)
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (None)
British Heart Foundation (CH/12/2/29428)
British Heart Foundation (RG/18/13/33946)