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Longitudinal Secretion of Paramyxovirus RNA in the Urine of Straw-Coloured Fruit Bats (Eidolon helvum).

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cam.issuedOnline2021-08-20
dc.contributor.authorJolma, Elli Rosa
dc.contributor.authorGibson, Louise
dc.contributor.authorSuu-Ire, Richard D
dc.contributor.authorFleischer, Grace
dc.contributor.authorAsumah, Samuel
dc.contributor.authorLanguon, Sylvester
dc.contributor.authorRestif, Olivier
dc.contributor.authorWood, James LN
dc.contributor.authorCunningham, Andrew A
dc.contributor.orcidJolma, Elli Rosa [0000-0002-9356-2891]
dc.contributor.orcidGibson, Louise [0000-0002-7293-1475]
dc.contributor.orcidCunningham, Andrew A [0000-0002-3543-6504]
dc.date.accessioned2021-11-10T00:30:15Z
dc.date.available2021-11-10T00:30:15Z
dc.date.issued2021-08-20
dc.description.abstractThe straw-coloured fruit bat (Eidolon helvum) is widespread in sub-Saharan Africa and is widely hunted for bushmeat. It is known to harbour a range of paramyxoviruses, including rubuloviruses and henipaviruses, but the zoonotic potential of these is unknown. We previously found a diversity of paramyxoviruses within a small, captive colony of E. helvum after it had been closed to contact with other bats for 5 years. In this study, we used under-roost urine collection to further investigate the paramyxovirus diversity and ecology in this colony, which had been closed to the outside for 10 years at the time of sampling. By sampling urine weekly throughout an entire year, we investigated possible seasonal patterns of shedding of virus or viral RNA. Using a generic paramyxovirus L-gene PCR, we detected eight distinct paramyxovirus RNA sequences. Six distinct sequences were detected using a Henipavirus-specific PCR that targeted a different region of the L-gene. Sequence detection had a bi-annual pattern, with the greatest peak in July, although different RNA sequences appeared to have different shedding patterns. No significant associations were detected between sequence detection and birthing season, environmental temperature or humidity, and no signs of illness were detected in any of the bats in the colony during the period of sample collection.
dc.format.mediumElectronic
dc.identifier.doi10.17863/CAM.77953
dc.identifier.eissn1999-4915
dc.identifier.issn1999-4915
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330510
dc.languageeng
dc.language.isoeng
dc.publisherMDPI AG
dc.publisher.urlhttp://dx.doi.org/10.3390/v13081654
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHenipavirus
dc.subjectParamyxoviridae
dc.subjectPteropodidae
dc.subjectRubulavirus
dc.subjectchiroptera
dc.subjectpersistence
dc.subjectAnimals
dc.subjectChiroptera
dc.subjectDisease Reservoirs
dc.subjectParamyxovirinae
dc.subjectRNA, Viral
dc.subjectSeasons
dc.subjectUrine
dc.subjectVirus Shedding
dc.titleLongitudinal Secretion of Paramyxovirus RNA in the Urine of Straw-Coloured Fruit Bats (Eidolon helvum).
dc.typeArticle
dcterms.dateAccepted2021-08-17
prism.issueIdentifier8
prism.publicationDate2021
prism.publicationNameViruses
prism.volume13
rioxxterms.licenseref.startdate2021-08-20
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3390/v13081654

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