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Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study

Published version
Peer-reviewed

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Authors

Tsvetanov, Kamen A.  ORCID logo  https://orcid.org/0000-0002-3178-6363
Spindler, Lennard 
Stamatakis, Emmanuel 
Newcombe, Virginia 
Lupson, Victoria 

Abstract

Human coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has multiple neurological consequences, but its long-term effect on brain health is still uncertain. The cerebrovascular consequences of COVID-19 may also affect brain health. We studied the chronic effect of COVID-19 on cerebrovascular health, in relation to acute severity, adverse clinical outcomes and in contrast to control group data. Here we assess cerebrovascular health in 45 patients six months after hospitalisation for acute COVID-19 using the resting state fluctuation amplitudes (RSFA) from functional magnetic resonance imaging, in relation to disease severity and in contrast with 42 controls. Acute COVID-19 severity was indexed by COVID-19 WHO Progression Scale, inflammatory and coagulatory biomarkers. Chronic widespread changes in frontoparietal RSFA were related to the severity of the acute COVID-19 episode. This relationship was not explained by chronic cardiorespiratory dysfunction, age, or sex. The level of cerebrovascular dysfunction was associated with cognitive, mental, and physical health at follow-up. The principal findings were consistent across univariate and multivariate approaches. The results indicate chronic cerebrovascular impairment following severe acute COVID-19, with the potential for long-term consequences on cognitive function and mental wellbeing.

Description

Keywords

COVID-19, Cardiorespiratory, Cerebrovascular, Microvascular, Neurology, SARS-CoV-2, Humans, COVID-19, SARS-CoV-2, Prospective Studies, Brain, Magnetic Resonance Imaging

Journal Title

NeuroImage: Clinical

Conference Name

Journal ISSN

2213-1582
2213-1582

Volume Title

Publisher

Elsevier
Sponsorship
Guarantors of Brain (Unknown)
National Institute for Health and Care Research (IS-BRC-1215-20014)
Wellcome Trust (220258/Z/20/Z)
Medical Research Council (MC_UU_00005/12)
MRC (unknown)
Medical Research Council (MC_G0802534)
British Academy (pf160048)
NIHR Cambridge Biomedical Research Centre (BRC-1215-20014) NIHR funding to the NIHR BioResource (RG94028) NIHR funding to the NIHR BioResource (RG85445) Guarantors of Brain (G101149) Wellcome Trust (220258) Medical Research Council (SUAG/010 RG91365) Medical Research Council (SUAG/051G101400) Addenbrookes Charitable Trust
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