Repository logo
 

Variations in whole brain radiation therapy fractionation for brain metastases in Victoria.

Simple item page
cam.issuedOnline2022-06-21
dc.contributor.authorChee, Lessandra Yan Shan
dc.contributor.authorSia, Joseph
dc.contributor.authorMilne, Roger L
dc.contributor.authorForoudi, Farshad
dc.contributor.authorMillar, Jeremy L
dc.contributor.authorOng, Wee Loon
dc.contributor.orcidSia, Joseph [0000-0002-9056-0903]
dc.contributor.orcidForoudi, Farshad [0000-0001-8387-0965]
dc.contributor.orcidMillar, Jeremy L [0000-0001-8202-8602]
dc.contributor.orcidOng, Wee Loon [0000-0001-6657-7193]
dc.date.accessioned2022-06-29T19:43:19Z
dc.date.available2022-06-29T19:43:19Z
dc.date.issued2022-12
dc.date.submitted2022-03-31
dc.date.updated2022-06-29T19:43:19Z
dc.description.abstractINTRODUCTION: We aim to evaluate the use of different whole brain radiation therapy (WBRT) fractionation schedules for brain metastases (BM) in Victoria, and the factors associated with it. METHODS: This is a population-based cohort of patients who received radiation therapy for BM between 2012 and 2017, as captured in the Victorian Radiotherapy Minimum Dataset. We excluded patients with primary brain tumour and those who had 'prophylactic' intent treatment. The Cochran-Armitage test was used to evaluate changing trend in WBRT fractionation. Multivariate multinomial logistic regressions were used to evaluate factors associated with WBRT fractionation. RESULTS: Of the 3111 patients who had WBRT, 1048 (45%), 1291 (42%) and 312 (13%) had ≤5, 6-10 and >10 fractions WBRT respectively. There was progressive increase in ≤5 fractions WBRT use over time, from 37% in 2012 to 50% in 2017 (P-trend < 0.001). In multivariate analyses, increasing age, patients with gastrointestinal cancer, patients living in remote/regional areas and more recent treatment were associated with the use of shorter WBRT fractionation (≤5 fractions), while patients who had WBRT plus stereotactic radiosurgery, and those treated in private institutions were associated with the use of prolonged WBRT fractionation (≥6 fractions). Three hundred eighty-nine (13%) patients died within 30 days of WBRT, of which 241 (64%), 119 (32%) and 17 (5%) had ≤5, 6-10 and > 10 fractions WBRT respectively. CONCLUSION: We observed large variations in WBRT fractionation that are associated with patient, tumour, treatment and institutional factors. It is important to continuously monitor and benchmark our practice in order to reduce potentially unwarranted variations.
dc.identifier.doi10.17863/CAM.85863
dc.identifier.eissn1754-9485
dc.identifier.issn1754-9477
dc.identifier.otherara13447
dc.identifier.otherjmiro-22-0176.r1
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338450
dc.languageen
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1111/1754-9485.13447
dc.subjectbrain metastases
dc.subjectwhole brain radiation therapy
dc.subjectHumans
dc.subjectCranial Irradiation
dc.subjectDose Fractionation, Radiation
dc.subjectRadiosurgery
dc.subjectBrain Neoplasms
dc.subjectBrain
dc.titleVariations in whole brain radiation therapy fractionation for brain metastases in Victoria.
dc.typeArticle
dcterms.dateAccepted2022-06-05
prism.publicationNameJ Med Imaging Radiat Oncol
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1111/1754-9485.13447

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
1754-9485.13447.xml
Size:
11.59 KB
Format:
Extensible Markup Language
Description:
Bibliographic metadata
Licence
http://creativecommons.org/licenses/by-nc-nd/4.0/
Download
Thumbnail Image
Name:
1754-9485.13447.pdf
Size:
467.69 KB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
http://creativecommons.org/licenses/by-nc-nd/4.0/
Download

Collections

Jisc Publications Router