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The essential role of complement in antibody-mediated resistance to Salmonella.

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cam.issuedOnline2018-10-10
dc.contributor.authorRossi, Omar
dc.contributor.authorCoward, Chris
dc.contributor.authorGoh, Yun Shan
dc.contributor.authorClaassens, Jill WC
dc.contributor.authorMacLennan, Calman A
dc.contributor.authorVerbeek, Sjef J
dc.contributor.authorMastroeni, Pietro
dc.contributor.orcidMastroeni, Pietro [0000-0003-3838-4962]
dc.date.accessioned2018-11-14T00:31:31Z
dc.date.available2018-11-14T00:31:31Z
dc.date.issued2019-01
dc.description.abstractVaccines can serve as essential tools to prevent bacterial diseases via the induction of long-lasting IgG responses. The efficacy of such vaccines depends on the effector mechanisms triggered by IgG. The complement system and Fc-gamma receptors (FcγRs) can potentially play a crucial role in IgG-mediated immunity against bacterial diseases. However, their relative importance in vivo is unclear, and has been the object of controversy and debate. In this brief study, we have used gene-targeted mice lacking either FcγRI, II, II and IV or the C3 complement component as well as a novel mouse strain lacking both C3 and FcγRs to conclusively show the essential role of complement in antibody-mediated host resistance to Salmonella enterica systemic infection. By comparing the effect of IgG2a antibodies against Salmonella O-antigen in gene-targeted mice, we demonstrate that the complement system is essential for the IgG-mediated reduction of bacterial numbers in the tissues.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.32423
dc.identifier.eissn1365-2567
dc.identifier.issn0019-2805
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285053
dc.languageeng
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1111/imm.13000
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSalmonella
dc.subjectin vivo
dc.subjectC3
dc.subjectFcγR
dc.subjectcomplement
dc.subjectinfection
dc.subjectAnimals
dc.subjectBacterial Load
dc.subjectComplement Activation
dc.subjectComplement C3
dc.subjectHumans
dc.subjectImmunity, Humoral
dc.subjectImmunoglobulin G
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectMice, Knockout
dc.subjectO Antigens
dc.subjectReceptors, IgG
dc.subjectSalmonella Infections
dc.subjectSalmonella Vaccines
dc.subjectSalmonella enterica
dc.titleThe essential role of complement in antibody-mediated resistance to Salmonella.
dc.typeArticle
dcterms.dateAccepted2018-08-20
prism.endingPage73
prism.issueIdentifier1
prism.publicationDate2019
prism.publicationNameImmunology
prism.startingPage69
prism.volume156
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M000982/1)
pubs.funder-project-idMedical Research Council (G0001245)
rioxxterms.licenseref.startdate2019-01
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1111/imm.13000

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