The past, present, and future of Leishmania genomics and transcriptomics.

It has been nearly 10 years since the completion of the first entire genome sequence of a Leishmania parasite. Genomic and transcriptomic analyses have advanced our understanding of the biology of Leishmania, and shed new light on the complex interactions occurring within the parasite-host-vector triangle. Here, we review these advances and examine potential avenues for translation of these discoveries into treatment and control programs. In addition, we argue for a strong need to explore how disease in dogs relates to that in humans, and how an improved understanding in line with the 'One Health' concept may open new avenues for the control of these devastating diseases.

Keywords

Leishmania infantum, One Health, bioinformatics, genome, high-throughput sequencing, host-parasite interactions, leishmaniases, metazoonosis, sand fly, transcriptome, Animals, Gene Expression Profiling, Genome, Protozoan, Genomics, Humans, Leishmania, Leishmaniasis, Transcriptome

Journal Title

Trends Parasitol

Journal ISSN

1471-4922
1471-5007

Volume Title

31

Publisher

Elsevier

Publisher DOI

https://doi.org/10.1016/j.pt.2014.12.012

Rights and licensing

Except where otherwised noted, this item's license is described as Attribution 2.0 UK: England & Wales

Sponsorship

Part of this article was conceived within the framework of of the EurNegVec COST Action TD1303. Funding from the Isaac Newton Trust/ Wellcome Trust ISSF/University of Cambridge Joint Research Grants Scheme to C.C. is gratefully acknowledged.

Collections

Scholarly Works - Veterinary Medicine
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