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Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.

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cam.depositDate2022-06-28
cam.issuedOnline2022-08-03
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cam.orpheus.successMon Aug 08 07:23:20 BST 2022 - Embargo updated
dc.contributor.authorTaylor-Williams, Michaela
dc.contributor.authorSpicer, Graham
dc.contributor.authorBale, Gemma
dc.contributor.authorBohndiek, Sarah E
dc.contributor.orcidBohndiek, Sarah [0000-0003-0371-8635]
dc.date.accessioned2022-06-28T23:30:28Z
dc.date.available2022-06-28T23:30:28Z
dc.date.issued2022-08
dc.date.updated2022-06-28T06:46:33Z
dc.description.abstractSIGNIFICANCE: Measurement and imaging of hemoglobin oxygenation are used extensively in the detection and diagnosis of disease; however, the applied instruments vary widely in their depth of imaging, spatiotemporal resolution, sensitivity, accuracy, complexity, physical size, and cost. The wide variation in available instrumentation can make it challenging for end users to select the appropriate tools for their application and to understand the relative limitations of different methods. AIM: We aim to provide a systematic overview of the field of hemoglobin imaging and sensing. APPROACH: We reviewed the sensing and imaging methods used to analyze hemoglobin oxygenation, including pulse oximetry, spectral reflectance imaging, diffuse optical imaging, spectroscopic optical coherence tomography, photoacoustic imaging, and diffuse correlation spectroscopy. RESULTS: We compared and contrasted the ability of different methods to determine hemoglobin biomarkers such as oxygenation while considering factors that influence their practical application. CONCLUSIONS: We highlight key limitations in the current state-of-the-art and make suggestions for routes to advance the clinical use and interpretation of hemoglobin oxygenation information.
dc.identifier.doi10.17863/CAM.85825
dc.identifier.eissn1560-2281
dc.identifier.issn1083-3668
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338412
dc.language.isoeng
dc.publisherSPIE-Intl Soc Optical Eng
dc.publisher.departmentDepartment of Physics
dc.publisher.urlhttp://dx.doi.org/10.1117/1.jbo.27.8.080901
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjecthemoglobin
dc.subjectimaging
dc.subjectsensing
dc.subjectspectroscopy
dc.subjectHemoglobins
dc.subjectOximetry
dc.subjectSpectrum Analysis
dc.subjectTomography, Optical Coherence
dc.titleNoninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.
dc.typeArticle
dcterms.dateAccepted2022-06-27
prism.publicationNameJ Biomed Opt
pubs.funder-project-idCancer Research UK (C14303/A17197)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/R003599/1)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1117/1.JBO.27.8.080901

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