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Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.

Published version
Peer-reviewed

Repository DOI


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Authors

Kamiza, Abram Bunya  ORCID logo  https://orcid.org/0000-0002-3919-7651
Soremekun, Opeyemi 
Cissé, Cheickna 

Abstract

Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic effects on lipid traits, we conducted a genome-wide meta-analysis, multi-trait analysis of GWAS (MTAG), and multi-trait fine-mapping (flashfm) in 125,000 individuals of African ancestry. Our meta-analysis and MTAG identified four and 14 novel loci associated with lipid traits, respectively. flashfm yielded an 18% mean reduction in the 99% credible set size compared to single-trait fine-mapping with JAM. Moreover, we identified more genetic variants with a posterior probability of causality >0.9 with flashfm than with JAM. In conclusion, we identified additional novel loci associated with lipid traits, and flashfm reduced the 99% credible set size to identify causal genetic variants associated with multiple lipid traits in African ancestry.

Description

Keywords

Humans, Black People, Genome-Wide Association Study, Lipids, Phenotype

Journal Title

Nat Commun

Conference Name

Journal ISSN

2041-1723
2041-1723

Volume Title

14

Publisher

Springer Science and Business Media LLC
Sponsorship
Medical Research Council (MR/R021368/1)
Medical Research Council (MC_UU_00002/4)