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Using alternatives to the car and risk of all-cause, cardiovascular and cancer mortality

cam.issuedOnline2018-05-21
dc.contributor.authorPanter, J
dc.contributor.authorMytton, O
dc.contributor.authorSharp, S
dc.contributor.authorBrage, S
dc.contributor.authorCummins, S
dc.contributor.authorLaverty, A
dc.contributor.authorWijndaele, K
dc.contributor.authorOgilvie, D
dc.contributor.orcidPanter, Jenna [0000-0001-8870-718X]
dc.contributor.orcidMytton, Oliver [0000-0003-3218-9912]
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.contributor.orcidWijndaele, Katrien [0000-0003-2199-7981]
dc.contributor.orcidOgilvie, David [0000-0002-0270-4672]
dc.date.accessioned2018-05-14T14:17:04Z
dc.date.available2018-05-14T14:17:04Z
dc.date.issued2018-11
dc.description.abstractAbstract: Objective: To investigate the associations between using alternatives to the car which are more active for commuting and non-commuting purposes and morbidity and mortality Methods: We conducted a prospective study using 358799 participants aged 37-73 from UK Biobank. Commute and non-commute travel were assessed at baseline in 2006-2010. We classified participants according to whether they relied exclusively on the car, or used alternative modes of transport that were more active at least some of the time. Main outcome measures were incident CVD and cancer, and CVD, cancer and all-cause mortality. We excluded events in the first two years and conducted analyses separately for those who regularly commuted and those who did not. Results: In maximally-adjusted models, regular commuters with more active patterns of travel on the commute had a lower risk of incident (HR 0.89, 95% CI 0.79 to 1.00) and fatal CVD (HR 0.70, 95% CI 0.51 to 0.95). Those regular commuters who also had more active patterns of non-commute travel had an even lower risk of fatal CVD (HR 0.57, 95% CI 0.39 to 0.85). Among those who were not regular commuters, more active patterns of travel were associated with a lower risk of all-cause mortality (HR 0.92, 95% CI 0.86 to 0.99). Conclusions: More active patterns of travel are associated with a reduced risk of incident and fatal CVD and all-cause mortality in adults. This is an important message for clinicians advising people about how to be physically active and reduce their risk of disease.
dc.description.sponsorshipJP, DO, SB and SS are supported by the Medical Research Council (Unit Programme Nos MC_UU_12015/1, MC_UU_12015/3 and MC_UU_12015/6) and KW is also supported by the British Heart Foundation (Intermediate Basic Science Research Fellowship grant No FS/12/58/29709). AAL is funded by the NIHR (RP 014-04-032), and the Public Health Policy Evaluation Unit are grateful for the support of the NIHR School of Public Health Research. This research was conducted using the UK Biobank resource (application No 20684). The work was also supported under the auspices of the Centre for Diet and Activity Research (CEDAR), a UKCRC Public Health Research Centre of Excellence at the University of Cambridge, for which funding from the British Heart Foundation, Economic and Social Research Council, Medical Research Council, National Institute for Health Research and the Wellcome Trust, under the auspices of the United Kingdom Clinical Research Collaboration, is gratefully acknowledged.
dc.identifier.doi10.17863/CAM.23037
dc.identifier.eissn1468-201X
dc.identifier.issn1355-6037
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/275770
dc.language.isoeng
dc.publisherBMJ
dc.publisher.urlhttp://heart.bmj.com/content/early/2018/04/16/heartjnl-2017-312699.info
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcardiac risk factors and prevention
dc.subjectcoronary artery disease
dc.subjectepidemiology
dc.subjecthypertension
dc.subjectstroke
dc.subjectAdult
dc.subjectAged
dc.subjectBicycling
dc.subjectCardiovascular Diseases
dc.subjectCause of Death
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasms
dc.subjectPhysical Fitness
dc.subjectProportional Hazards Models
dc.subjectRisk Adjustment
dc.subjectSurveys and Questionnaires
dc.subjectSurvival Analysis
dc.subjectTransportation
dc.subjectUnited Kingdom
dc.subjectWalking
dc.titleUsing alternatives to the car and risk of all-cause, cardiovascular and cancer mortality
dc.typeArticle
dcterms.dateAccepted2018-02-25
prism.publicationNameHeart
pubs.funder-project-idWellcome Trust (087636/Z/08/Z)
pubs.funder-project-idEconomic and Social Research Council (ES/G007462/1)
pubs.funder-project-idMedical Research Council (MR/K023187/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/6)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idTCC (None)
rioxxterms.licenseref.startdate2018-02-25
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1136/heartjnl-2017-312699

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