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From pulsatile apicomedial contractility to effective epithelial mechanics.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Blanchard, Guy B 
Étienne, Jocelyn 
Gorfinkiel, Nicole 

Abstract

We review recent developments in the understanding of the biomechanics of apicomedial actomyosin and how its contractility can tense and deform tissue. Myosin pulses are driven by a biochemical oscillator but how they are modulated by the mechanical context remains unclear. On the other hand, the emergence of tissue behaviour is highly dependent on the material properties of actin, on how strongly components are connected and on the influence of neighbouring tissues. We further review the use of constitutive equations in exploring the mechanics of epithelial apices dominated by apicomedial Myosin contractility.

Description

Keywords

Actins, Actomyosin, Biomechanical Phenomena, Epithelium, Humans, Myosins

Journal Title

Curr Opin Genet Dev

Conference Name

Journal ISSN

0959-437X
1879-0380

Volume Title

51

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (099234/Z/12/Z)
Biotechnology and Biological Sciences Research Council (BB/J010278/1)