From pulsatile apicomedial contractility to effective epithelial mechanics.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Blanchard, Guy B
Étienne, Jocelyn
Gorfinkiel, Nicole
Abstract
We review recent developments in the understanding of the biomechanics of apicomedial actomyosin and how its contractility can tense and deform tissue. Myosin pulses are driven by a biochemical oscillator but how they are modulated by the mechanical context remains unclear. On the other hand, the emergence of tissue behaviour is highly dependent on the material properties of actin, on how strongly components are connected and on the influence of neighbouring tissues. We further review the use of constitutive equations in exploring the mechanics of epithelial apices dominated by apicomedial Myosin contractility.
Description
Keywords
Actins, Actomyosin, Biomechanical Phenomena, Epithelium, Humans, Myosins
Journal Title
Curr Opin Genet Dev
Conference Name
Journal ISSN
0959-437X
1879-0380
1879-0380
Volume Title
51
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Wellcome Trust (099234/Z/12/Z)
Biotechnology and Biological Sciences Research Council (BB/J010278/1)
Biotechnology and Biological Sciences Research Council (BB/J010278/1)