Linear system identifiability from single-cell data
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Peer-reviewed
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Abstract
In this brief article, we prove a result on identifiability of a discrete-time linear system from measurements of the mean and the covariance of the state distribution, obtained from population snapshot observations over time. We show that three time points of such measurements are sufficient for unique identifiability. This is in stark contrast to identifiability from time series data, in which case n+1 measurements are required for identifiability of an n-dimensional system. Robustness of the identifiability is investigated by numerical experiments. The work is motivated by the problem of gene regulatory network inference from single-cell data and will serve as a foundation for the development of modelling algorithms.
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Keywords
System identifiability, Systems biology, Single-cell data, Population snapshot, Gene regulatory networks, Linear stochastic systems
Journal Title
Systems and Control Letters
Conference Name
Journal ISSN
0167-6911
1872-7956
1872-7956
Volume Title
165
Publisher
Elsevier BV