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Improving outcomes in high-risk, nonmetastatic renal cancer: new data and ongoing trials.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Blick, Chris 
Ritchie, Alastair WS 
Eisen, Timothy 
Stewart, Grant D 

Abstract

High-risk, localized renal cancer is associated with recurrence rates of up to 75% at 10 years. The outcomes of patients at this disease stage depend on optimal patient stratification, surgical management and systemic therapy selection. Current evidence does not support the use of adjuvant therapy in patients with high-risk, localized disease. During the past 12 months, the results of large, randomized-controlled trials of adjuvant tyrosine kinase inhibitor (TKI) treatment, such as ASSURE and S-TRAC, have been published, but their findings are conflicting. Whether TKIs will become standard of care in the adjuvant setting depends on the long-term data from ongoing trials. In addition, several new trials that evaluate the utility of novel immune checkpoint inhibitors in this patient group are currently recruiting. The management of renal cancer is likely to evolve at a rapid pace over the next few years and matching patients with the appropriate therapeutic regimen is likely to be a focus of future research.

Description

Keywords

Carcinoma, Renal Cell, Combined Modality Therapy, Humans, Kidney Neoplasms, Nephrectomy, Prognosis

Journal Title

Nat Rev Urol

Conference Name

Journal ISSN

1759-4812
1759-4820

Volume Title

14

Publisher

Springer Science and Business Media LLC