GLUT4 On the move.


Type
Article
Change log
Authors
Fazakerley, Daniel J 
Koumanov, Francoise 
Holman, Geoffrey D 
Abstract

Insulin rapidly stimulates GLUT4 translocation and glucose transport in fat and muscle cells. Signals from the occupied insulin receptor are translated into downstream signalling changes in serine/threonine kinases within timescales of seconds, and this is followed by delivery and accumulation of the glucose transporter GLUT4 at the plasma membrane. Kinetic studies have led to realisation that there are distinct phases of this stimulation by insulin. There is a rapid initial burst of GLUT4 delivered to the cell surface from a subcellular reservoir compartment and this is followed by a steady-state level of continuing stimulation in which GLUT4 recycles through a large itinerary of subcellular locations. Here, we provide an overview of the phases of insulin stimulation of GLUT4 translocation and the molecules that are currently considered to activate these trafficking steps. Furthermore, we suggest how use of new experimental approaches together with phospho-proteomic data may help to further identify mechanisms for activation of these trafficking processes.

Description
Keywords
GLUT4, glucose transport, insulin, membrane traffic, membrane trafficking kinetics, signal transduction
Journal Title
Biochemical Journal
Conference Name
Journal ISSN
0264-6021
1470-8728
Volume Title
479
Publisher
Portland Press
Sponsorship
Medical Research Council (MR/S007091/1)