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Buffering variability in cell regulation motifs close to criticality.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Proverbio, Daniele 
Montanari, Arthur N 
Skupin, Alexander 
Gonçalves, Jorge 

Abstract

Bistable biological regulatory systems need to cope with stochastic noise to fine tune their function close to bifurcation points. Here, we study stability properties of this regime in generic systems to demonstrate that cooperative interactions buffer system variability, hampering noise-induced regime shifts. Our analysis also shows that, in the considered cooperativity range, impending regime shifts can be generically detected by statistical early warning signals from distributional data. Our generic framework, based on minimal models, can be used to extract robustness and variability properties of more complex models and empirical data close to criticality.

Description

Keywords

40 Engineering, 49 Mathematical Sciences, 51 Physical Sciences

Journal Title

Phys Rev E

Conference Name

Journal ISSN

2470-0045
2470-0053

Volume Title

106

Publisher

American Physical Society (APS)