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Novel Approach for Assessing Postinfarct Myocardial Injury and Inflammation Using Hybrid Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging.

Published version
Peer-reviewed

Type

Article

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Authors

Ćorović, Andrej 
Gopalan, Deepa 
Wall, Christopher 
Peverelli, Marta 

Abstract

Post-infarct inflammation and its resolution modulate ischemic injury after myocardial infarction (MI). While cardiac magnetic resonance imaging (MRI) is useful for assessing ventricular function, viability and structural complications after MI, as well as detecting edema associated with acute inflammation, it lacks specificity for immune cell activity and may be less sensitive for identifying persistent, low-grade inflammation. Positron emission tomography (PET) imaging with 18F-Fluorodeoxyglucose (FDG) and other more specifically-targeted tracers could have a role for quantifying infarct-related inflammation and identifying a link with adverse myocardial remodelling.1 Focal myocardial uptake of the somatostatin receptor 2 (SST2) PET tracer 68Ga-DOTATATE has been observed in patients with prior infarction,2 however the clinical relevance of this finding remains unknown. Here we report an illustrative case from an ongoing study aimed to evaluate a novel, integrated approach for assessing post-infarct myocardial injury and inflammation using hybrid SST2 PET/MRI.

Description

Keywords

inflammation, magnetic resonance imaging, myocardial infarction, positron emission tomography, receptors, somatostatin, Humans, Receptors, Somatostatin, Magnetic Resonance Imaging, Positron-Emission Tomography, Inflammation

Journal Title

Circ Cardiovasc Imaging

Conference Name

Journal ISSN

1941-9651
1942-0080

Volume Title

16

Publisher

Ovid Technologies (Wolters Kluwer Health)
Sponsorship
Wellcome Trust (211100/Z/18/Z)
British Heart Foundation (FS/CRTF/20/24035)
British Heart Foundation (CH/2000003/12800)