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Breast, Prostate, Colorectal, and Lung Cancer Incidence and Risk Factors in Women Who Have Sex with Women and Men Who Have Sex with Men: A Cross-Sectional and Longitudinal Analysis Using UK Biobank

Published version
Peer-reviewed

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Authors

Underwood, Sarah 
Lyratzopoulos, Georgios  ORCID logo  https://orcid.org/0000-0002-2873-7421
Saunders, Catherine L  ORCID logo  https://orcid.org/0000-0002-3127-3218

Abstract

jats:pBackground. There is limited evidence about cancer incidence for lesbian, gay and bisexual women and men, although the prevalence of cancer risk factors may be higher. Aim. To describe cancer incidence for four common cancers (breast, lung, colorectal and prostate). Methods. This project used UK Biobank participant data. We explored risk factor prevalence (age, deprivation, ethnicity, smoking, alcohol intake, obesity, parity, and sexual history), and calculated cancer risk, for six groups defined based on sexual history; women who have sex exclusively with men (WSEM), or women (WSEW), women who have sex with men and women (WSWM); men who have sex exclusively with women (MSEW), or men (MSEM), and men who have sex with women and men (MSWM). Results. WSEW, WSWM, MSEM, and MSMW were younger, more likely to smoke, and to live in more deprived neighbourhoods. We found no evidence of an association between sexual history and breast, colorectal, or prostate cancer in age-adjusted models. Lung cancer incidence was higher for WSWM compared with WSEM, HR (95%CI) 1.78 (1.28–2.48), p = 0.0005, and MSWM compared with MSEW, 1.43 (1.03–1.99), p = 0.031; after adjustment for smoking, this difference was no longer significant. Conclusions. Sexual minority groups have a higher risk for lung cancer, due to greater exposure to smoking.</jats:p>

Description

Peer reviewed: True

Keywords

Article, cancer epidemiology, cancer risk, cancer incidence, inequalities, sexual minority health

Journal Title

Cancers

Conference Name

Journal ISSN

2072-6694

Volume Title

Publisher

MDPI AG
Sponsorship
Cancer Research UK Advanced Clinician Scientist Fellowship (C18081/A18180)