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A Systematic Review on Clinical and Health-Related Quality of Life Outcomes following Total Gastrectomy in Patients with Hereditary Diffuse Gastric Cancer

Published version
Peer-reviewed

Repository DOI


Type

Article

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Authors

Lim, Hui Jun 
di Pietro, Massimiliano  ORCID logo  https://orcid.org/0000-0003-4866-7026
O’Neill, J Robert 

Abstract

jats:pHereditary diffuse gastric cancer (HDGC) is an autosomal-dominant syndrome associated with early onset diffuse gastric cancer. Definitive treatment is prophylactic total gastrectomy (PTG) associated with significant morbidity. Studies published from January 2000 to December 2022 reporting clinical, histopathological or health-related quality of life outcomes in HDGC patients undergoing PTG were identified. The study quality was assessed by the “Newcastle–Ottawa scale”. Of the 257 articles screened, 21 were selected. A total of 353 patients were examined in 15 studies that reported surgical outcomes. The median age was 42 years old. The median major complication and mortality rates were 19.2% and 0.3%, respectively. The most common complications were wound infection at 4.8% followed by anastomotic leak and pulmonary complications at 4.5% each. Following PTG, 88.6% of patients had early lesions amongst 414 patients. The mean/median number of signet ring cell carcinoma foci in the gastrectomy specimens was from 2 to 78. All cases were stage 1 with no lymph node involvement. There was a wide range of psychosocial effects following PTG closely related to the physical symptoms. It is imperative for patients to receive comprehensive preoperative counselling to make an informed decision and be followed up under the care of a multidisciplinary team.</jats:p>

Description

Keywords

32 Biomedical and Clinical Sciences, 3211 Oncology and Carcinogenesis, Rare Diseases, Cancer, Digestive Diseases, Cancer, 3 Good Health and Well Being

Journal Title

Cancers

Conference Name

Journal ISSN

2072-6694
2072-6694

Volume Title

16

Publisher

MDPI AG
Sponsorship
National Institute for Health and Care Research (IS-BRC-1215-20014)