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Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.

cam.issuedOnline2021-10-27
dc.contributor.authorKirschner, Matthias
dc.contributor.authorHodzic-Santor, Benazir
dc.contributor.authorAntoniades, Mathilde
dc.contributor.authorNenadic, Igor
dc.contributor.authorKircher, Tilo
dc.contributor.authorKrug, Axel
dc.contributor.authorMeller, Tina
dc.contributor.authorGrotegerd, Dominik
dc.contributor.authorFornito, Alex
dc.contributor.authorArnatkeviciute, Aurina
dc.contributor.authorBellgrove, Mark A
dc.contributor.authorTiego, Jeggan
dc.contributor.authorDannlowski, Udo
dc.contributor.authorKoch, Katharina
dc.contributor.authorHülsmann, Carina
dc.contributor.authorKugel, Harald
dc.contributor.authorEnneking, Verena
dc.contributor.authorKlug, Melissa
dc.contributor.authorLeehr, Elisabeth J
dc.contributor.authorBöhnlein, Joscha
dc.contributor.authorGruber, Marius
dc.contributor.authorMehler, David
dc.contributor.authorDeRosse, Pamela
dc.contributor.authorMoyett, Ashley
dc.contributor.authorBaune, Bernhard T
dc.contributor.authorGreen, Melissa
dc.contributor.authorQuidé, Yann
dc.contributor.authorPantelis, Christos
dc.contributor.authorChan, Raymond
dc.contributor.authorWang, Yi
dc.contributor.authorEttinger, Ulrich
dc.contributor.authorDebbané, Martin
dc.contributor.authorDerome, Melodie
dc.contributor.authorGaser, Christian
dc.contributor.authorBesteher, Bianca
dc.contributor.authorDiederen, Kelly
dc.contributor.authorSpencer, Tom J
dc.contributor.authorFletcher, Paul
dc.contributor.authorRössler, Wulf
dc.contributor.authorSmigielski, Lukasz
dc.contributor.authorKumari, Veena
dc.contributor.authorPremkumar, Preethi
dc.contributor.authorPark, Haeme RP
dc.contributor.authorWiebels, Kristina
dc.contributor.authorLemmers-Jansen, Imke
dc.contributor.authorGilleen, James
dc.contributor.authorAllen, Paul
dc.contributor.authorKozhuharova, Petya
dc.contributor.authorMarsman, Jan-Bernard
dc.contributor.authorLebedeva, Irina
dc.contributor.authorTomyshev, Alexander
dc.contributor.authorMukhorina, Anna
dc.contributor.authorKaiser, Stefan
dc.contributor.authorFett, Anne-Kathrin
dc.contributor.authorSommer, Iris
dc.contributor.authorSchuite-Koops, Sanne
dc.contributor.authorPaquola, Casey
dc.contributor.authorLarivière, Sara
dc.contributor.authorBernhardt, Boris
dc.contributor.authorDagher, Alain
dc.contributor.authorGrant, Phillip
dc.contributor.authorvan Erp, Theo GM
dc.contributor.authorTurner, Jessica A
dc.contributor.authorThompson, Paul M
dc.contributor.authorAleman, André
dc.contributor.authorModinos, Gemma
dc.contributor.orcidKirschner, Matthias [0000-0002-9486-1439]
dc.contributor.orcidFornito, Alex [0000-0003-0866-3477]
dc.contributor.orcidBellgrove, Mark A [0000-0003-0186-8349]
dc.contributor.orcidTiego, Jeggan [0000-0001-7835-6398]
dc.contributor.orcidDannlowski, Udo [0000-0002-0623-3759]
dc.contributor.orcidKugel, Harald [0000-0002-4349-1984]
dc.contributor.orcidBöhnlein, Joscha [0000-0002-9870-5599]
dc.contributor.orcidDeRosse, Pamela [0000-0003-0823-8163]
dc.contributor.orcidPantelis, Christos [0000-0002-9565-0238]
dc.contributor.orcidChan, Raymond [0000-0001-7571-6933]
dc.contributor.orcidKumari, Veena [0000-0002-9635-5505]
dc.contributor.orcidWiebels, Kristina [0000-0002-5360-5965]
dc.contributor.orcidMukhorina, Anna [0000-0003-2369-5493]
dc.contributor.orcidLarivière, Sara [0000-0001-5701-1307]
dc.contributor.orcidDagher, Alain [0000-0002-0945-5779]
dc.contributor.orcidvan Erp, Theo GM [0000-0002-2465-2797]
dc.contributor.orcidTurner, Jessica A [0000-0003-0076-8434]
dc.contributor.orcidModinos, Gemma [0000-0002-7870-066X]
dc.date.accessioned2022-04-29T15:00:37Z
dc.date.available2022-04-29T15:00:37Z
dc.date.issued2022-02
dc.date.submitted2021-04-15
dc.date.updated2022-04-29T15:00:36Z
dc.description.abstractNeuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. The sample comprised 3004 unmedicated healthy individuals (12-68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r = 0.067, pFDR = 0.02). The cortical thickness profile in schizotypy was positively correlated with cortical abnormalities in SZ (r = 0.285, pspin = 0.024), but not BD (r = 0.166, pspin = 0.205) or MDD (r = -0.274, pspin = 0.073). The schizotypy-related subcortical volume pattern was negatively correlated with subcortical abnormalities in SZ (rho = -0.690, pspin = 0.006), BD (rho = -0.672, pspin = 0.009), and MDD (rho = -0.692, pspin = 0.004). Comprehensive mapping of schizotypy-related brain morphometry in the general population revealed a significant relationship between higher schizotypy and thicker mOFC/vmPFC, in the absence of confounding effects due to antipsychotic medication or disease chronicity. The cortical pattern similarity between schizotypy and schizophrenia yields new insights into a dimensional neurobiological continuity across the extended psychosis phenotype.
dc.identifier.doi10.17863/CAM.84034
dc.identifier.eissn1476-5578
dc.identifier.issn1359-4184
dc.identifier.others41380-021-01359-9
dc.identifier.other1359
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336614
dc.languageen
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41380-021-01359-9
dc.subjectBipolar Disorder
dc.subjectFemale
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectPsychotic Disorders
dc.subjectSchizophrenia
dc.subjectSchizotypal Personality Disorder
dc.titleCortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.
dc.typeArticle
dcterms.dateAccepted2021-10-08
prism.endingPage1176
prism.issueIdentifier2
prism.publicationNameMol Psychiatry
prism.startingPage1167
prism.volume27
pubs.funder-project-idWellcome Trust (Wellcome) (202397/Z/16/Z)
pubs.funder-project-idU.S. Department of Health & Human Services | National Institutes of Health (NIH) (EB020403)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41380-021-01359-9

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