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Parental inflammatory bowel disease and autism in children.

Published version
Peer-reviewed

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Authors

Sadik, Aws 
Pagoni, Panagiota 

Abstract

Evidence linking parental inflammatory bowel disease (IBD) with autism in children is inconclusive. We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based cohort study using Swedish registers, we found evidence of associations between parental diagnoses of IBD and autism in children. Polygenic risk score analyses of the Avon Longitudinal Study of Parents and Children suggested associations between maternal genetic liability to IBD and autistic traits in children. Two-sample Mendelian randomization analyses provided evidence of a potential causal effect of genetic liability to IBD, especially ulcerative colitis, on autism. Linkage disequilibrium score regression did not indicate a genetic correlation between IBD and autism. Triangulating evidence from these four complementary approaches, we found evidence of a potential causal link between parental, particularly maternal, IBD and autism in children. Perinatal immune dysregulation, micronutrient malabsorption and anemia may be implicated.

Description

Funder: the South-Eastern Norway Regional Health Authority (2020022, 2018059) and the Research Council of Norway (274611, 288083)


Funder: NIMH (1U01MH109514-01)


Funder: the MQ: Transforming Mental Health (grant code: MQDS17/40), the Medical Research Council UK (grant code: MC_PC_17213 and grant code: MR/S037675/1), NIHR (project code: NIHR202646), and the BMA Foundation (J Moulton grant 2019)


Funder: NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol


Funder: the Swedish Research Council (VR2017-02900)

Keywords

Autism Spectrum Disorder, Autistic Disorder, Child, Cohort Studies, Colitis, Ulcerative, Female, Humans, Inflammatory Bowel Diseases, Longitudinal Studies, Pregnancy

Journal Title

Nat Med

Conference Name

Journal ISSN

1078-8956
1546-170X

Volume Title

28

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (Wellcome) (215379/Z/19/Z, 201486/Z/16/Z)
Lundbeckfonden (Lundbeck Foundation) (R102-A9118, R155-2014-1724, and R248-2017-2003)