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Microenvironmental modulation of the developing tumour: an immune-stromal dialogue.

Published version
Peer-reviewed

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Authors

Jones, James O 
Moody, William M 
Shields, Jacqueline D  ORCID logo  https://orcid.org/0000-0003-2153-9710

Abstract

Successful establishment of a tumour relies on a cascade of interactions between cancer cells and stromal cells within an evolving microenvironment. Both immune and nonimmune cellular components are key factors in this process, and the individual players may change their role from tumour elimination to tumour promotion as the microenvironment develops. While the tumour-stroma crosstalk present in an established tumour is well-studied, aspects in the early tumour or premalignant microenvironment have received less attention. This is in part due to the challenges in studying this process in the clinic or in mouse models. Here, we review the key anti- and pro-tumour factors in the early microenvironment and discuss how understanding this process may be exploited in the clinic.

Description

Keywords

cancer-associated fibroblast, extracellular matrix, immune, malignant transformation, stroma, tumour microenvironment, Animals, Humans, Mice, Neoplasms, Stromal Cells, Tumor Microenvironment

Journal Title

Mol Oncol

Conference Name

Journal ISSN

1574-7891
1878-0261

Volume Title

15

Publisher

Wiley
Sponsorship
Medical Research Council (MC_UU_12022/5)