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New closed-loop insulin systems

Published version
Peer-reviewed

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Authors

Abstract

Abstract: Advances in diabetes technologies have enabled the development of automated closed-loop insulin delivery systems. Several hybrid closed-loop systems have been commercialised, reflecting rapid transition of this evolving technology from research into clinical practice, where it is gradually transforming the management of type 1 diabetes in children and adults. In this review we consider the supporting evidence in terms of glucose control and quality of life for presently available closed-loop systems and those in development, including dual-hormone closed-loop systems. We also comment on alternative ‘do-it-yourself’ closed-loop systems. We remark on issues associated with clinical adoption of these approaches, including training provision, and consider limitations of presently available closed-loop systems and areas for future enhancements to further improve outcomes and reduce the burden of diabetes management. Graphical abstract:

Description

Keywords

Review, Insulin 100 – celebrating 100 years of insulin, Artificial pancreas, Automated insulin delivery, Hybrid closed-loop, Type 1 diabetes

Journal Title

Diabetologia

Conference Name

Journal ISSN

0012-186X
1432-0428

Volume Title

64

Publisher

Springer Berlin Heidelberg
Sponsorship
Wellcome Trust Strategic Award (100574/Z/12/Z)
European Union Horizon 2020 research and innovation program (731560)