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Brown and beige fat: From molecules to physiology and pathophysiology.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Carobbio, Stefania 
Guénantin, Anne-Claire 
Samuelson, Isabella  ORCID logo  https://orcid.org/0000-0001-8395-3090
Bahri, Myriam 
Vidal-Puig, Antonio  ORCID logo  https://orcid.org/0000-0003-4220-9577

Abstract

The adipose organ portrays adipocytes of diverse tones: white, brown and beige, each type with distinct functions. Adipocytes orchestrate their adaptation and expansion to provide storage to excess nutrients, the quick mobilisation of fuel to supply peripheral functional demands, insulation, and, in their thermogenic form, heat generation to maintain core body temperature. Thermogenic adipocytes could be targets for anti-obesity and anti-diabetic therapeutic approaches aiming to restore adipose tissue functionality and increase energy dissipation. However, for thermogenic adipose tissue to become therapeutically relevant, a better understanding of its development and origins, its progenitors and their characteristics and the composition of its niche, is essential. Also crucial is the identification of stimuli and molecules promoting its specific differentiation and activation. Here we highlight the structural/cellular differences between human and rodent brown adipose tissue and discuss how obesity and metabolic complication affects brown and beige cells as well as how they could be targeted to improve their activation and improve global metabolic homeostasis. Finally, we describe the limitations of current research models and the advantages of new emerging approaches.

Description

Keywords

Metabolic disease models, Obesity, Pluripotent stem cells, Thermogenesis, Thermogenic activators, Thermogenic adipocytes, Adipocytes, Adipokines, Adipose Tissue, Beige, Adipose Tissue, Brown, Animals, Humans, Thermogenesis

Journal Title

Biochim Biophys Acta Mol Cell Biol Lipids

Conference Name

Journal ISSN

1388-1981
1879-2618

Volume Title

1864

Publisher

Elsevier BV

Rights

All rights reserved
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/J009865/1)
Medical Research Council (MC_UU_12012/2)
European Research Council (669879)
British Heart Foundation (None)
British Heart Foundation (None)
Medical Research Council (G0600717)
Medical Research Council (G0802051)
MRC (MC_UU_00014/2)
MRC (MC_UU_00014/5)
Medical Research Council (MC_PC_12012)
Medical Research Council (G0600717/1)