Chromatin Architecture in the Fly: Living without CTCF/Cohesin Loop Extrusion?: Alternating Chromatin States Provide a Basis for Domain Architecture in Drosophila


Type
Article
Change log
Abstract

The organization of the genome into topological domains (TADs) appears to be a fundamental process occurring across a wide range of eukaryote organisms, and it likely plays an important role in providing an architectural foundation for gene regulation. Initial studies emphasized the remarkable parallels between TAD organization in organisms as diverse as Drosophila and mammals. However, whereas CTCF/cohesin loop extrusion is emerging as a key mechanism for the formation of mammalian topological domains, the genome organization in Drosophila appears to depend primarily on the partitioning of chromatin state domains. We discuss recent work suggesting a fundamental conserved role of chromatin state in building domain architecture, and we consider insights into genome organization from recent studies in Drosophila.

Description
Keywords
3101 Biochemistry and Cell Biology, 3105 Genetics, 31 Biological Sciences, Genetics, Human Genome, 1.1 Normal biological development and functioning, 1 Underpinning research, Generic health relevance, Amino Acid Sequence, Animals, CCCTC-Binding Factor, Cell Cycle Proteins, Chromatin, Chromosomal Proteins, Non-Histone, Conserved Sequence, Drosophila, Drosophila Proteins, Genome, Insect, Mammals, Protein Domains, Transcription, Genetic
Journal Title
BioEssays
Conference Name
Journal ISSN
0265-9247
1521-1878
Volume Title
41
Publisher
John Wiley & Sons Inc.
Rights
All rights reserved
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M007081/1)
Biotechnology and Biological Sciences Research Council (Grant BB/M007081/1)