Multi-length scale bioprinting towards simulating microenvironmental cues.


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Authors
Gill, Elisabeth L 
Li, Xia 
Birch, Mark A 
Huang, Yan Yan Shery 
Abstract

It is envisaged that the creation of cellular environments at multiple length scales, that recapitulate in vivo bioactive and structural roles, may hold the key to creating functional, complex tissues in the laboratory. This review considers recent advances in biofabrication and bioprinting techniques across different length scales. Particular focus is placed on 3D printing of hydrogels and fabrication of biomaterial fibres that could extend the feature resolution and material functionality of soft tissue constructs. The outlook from this review discusses how one might create and simulate microenvironmental cues in vitro. A fabrication platform that integrates the competencies of different biofabrication technologies is proposed. Such a multi-process, multiscale fabrication strategy may ultimately translate engineering capability into an accessible life sciences toolkit, fulfilling its potential to deliver in vitro disease models and engineered tissue implants.

Description
Keywords
3D bioprinting, Additive manufacturing, Disease modelling, Electrospinning, Microenvironment, Tissue engineering
Journal Title
Biodes Manuf
Conference Name
Journal ISSN
2096-5524
2522-8552
Volume Title
1
Publisher
Springer Science and Business Media LLC
Sponsorship
Engineering and Physical Sciences Research Council (EP/M018989/1)
European Research Council (758865)
Medical Research Council (MC_PC_12009)