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Gene drives for schistosomiasis transmission control.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Maier, Theresa 
Wheeler, Nicolas James 
Namigai, Erica KO 
Tycko, Josh 
Grewelle, Richard Ernest 

Abstract

Schistosomiasis is one of the most important and widespread neglected tropical diseases (NTD), with over 200 million people infected in more than 70 countries; the disease has nearly 800 million people at risk in endemic areas. Although mass drug administration is a cost-effective approach to reduce occurrence, extent, and severity of the disease, it does not provide protection to subsequent reinfection. Interventions that target the parasites' intermediate snail hosts are a crucial part of the integrated strategy required to move toward disease elimination. The recent revolution in gene drive technology naturally leads to questions about whether gene drives could be used to efficiently spread schistosome resistance traits in a population of snails and whether gene drives have the potential to contribute to reduced disease transmission in the long run. Responsible implementation of gene drives will require solutions to complex challenges spanning multiple disciplines, from biology to policy. This Review Article presents collected perspectives from practitioners of global health, genome engineering, epidemiology, and snail/schistosome biology and outlines strategies for responsible gene drive technology development, impact measurements of gene drives for schistosomiasis control, and gene drive governance. Success in this arena is a function of many factors, including gene-editing specificity and efficiency, the level of resistance conferred by the gene drive, how fast gene drives may spread in a metapopulation over a complex landscape, ecological sustainability, social equity, and, ultimately, the reduction of infection prevalence in humans. With combined efforts from across the broad global health community, gene drives for schistosomiasis control could fortify our defenses against this devastating disease in the future.

Description

Keywords

Animals, Disease Reservoirs, Disease Resistance, Disease Transmission, Infectious, Gene Drive Technology, Humans, Schistosomiasis, Snails

Journal Title

PLoS Negl Trop Dis

Conference Name

Journal ISSN

1935-2727
1935-2735

Volume Title

Publisher

Public Library of Science (PLoS)