GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila.

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The Drosophila melanogaster larval neuromuscular system is extensively used by researchers to study neuronal cell biology, and Drosophila glutamatergic motor neurons have become a major model system. There are two main Types of glutamatergic motor neurons, Ib and Is, with different structural and physiological properties at synaptic level at the neuromuscular junction. To generate genetic tools to identify and manipulate motor neurons of each Type, we screened for GAL4 driver lines for this purpose. Here we describe GAL4 drivers specific for examples of neurons within each Type, Ib or Is. These drivers showed high expression levels and were expressed in only few motor neurons, making them amenable tools for specific studies of both axonal and synapse biology in identified Type I motor neurons.

Drosophila, GAL4, NMJ, glutamatergic synapse, motor neuron, neuromuscular junction, synaptic boutons, Animals, Drosophila Proteins, Drosophila melanogaster, Glutamic Acid, Green Fluorescent Proteins, Motor Neurons, Neuromuscular Junction, Transcription Factors
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G3 (Bethesda)
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Oxford University Press (OUP)
Biotechnology and Biological Sciences Research Council (BB/L021706/1)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (745007)
This work was supported by grant BB/L021706/1 from the UK Biotechnology and Biological Sciences Research Council to CJO’K, and Marie Sklodowska-Curie 19 fellowship 745007 from the European Union Horizon 2020 research and innovation programme to JJPM.
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