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Emergence of neuronal diversity from patterning of telencephalic progenitors.



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Azzarelli, Roberta 
Hardwick, Laura JA 


During central nervous system (CNS) development, hundreds of distinct neuronal subtypes are generated from a single layer of multipotent neuroepithelial progenitor cells. Within the rostral CNS, initial regionalization of the telencephalon marks the territories where the cerebral cortex and the basal ganglia originate. Subsequent refinement of the primary structures determines the formation of domains of differential gene expression, where distinct fate-restricted progenitors are located. To understand how diversification of neural progenitors and neurons is achieved in the telencephalon, it is important to address early and late patterning events in this context. In particular, important questions include: How does the telencephalon become specified and regionalized along the major spatial axes? Within each region, are the differences in neuronal subtypes established at the progenitor level or at the postmitotic stage? If distinct progenitors exist that are committed to subtype-specific neuronal lineages, how does the diversification emerge? What is the contribution of positional and temporal cues and how is this information integrated into the intrinsic programs of cell identity? WIREs For further resources related to this article, please visit the WIREs website.



Cell Differentiation, Cell Lineage, Gene Expression Regulation, Developmental, Humans, Models, Neurological, Morphogenesis, Neural Stem Cells, Telencephalon, Transcription Factors

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Wiley Interdiscip Rev Dev Biol

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John Wiley and Sons Inc.
Medical Research Council (G0700758)
Medical Research Council (MR/K018329/1)
Medical Research Council (MR/L021129/1)
Medical Research Council (G0700758/1)
This work was supported by Medical Research Council (MRC) grants G0700758 and MR/K018329/1 and Doctoral Training Award (LH); RA is supported by an MRC postdoctoral fellowship.