Repository logo
 

Biophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria.

Simple item page
cam.issuedOnline2022-05-31
dc.contributor.authorIntroini, Viola
dc.contributor.authorGovendir, Matt A
dc.contributor.authorRayner, Julian C
dc.contributor.authorCicuta, Pietro
dc.contributor.authorBernabeu, Maria
dc.contributor.orcidRayner, Julian [0000-0002-9835-1014]
dc.date.accessioned2022-06-14T08:00:23Z
dc.date.available2022-06-14T08:00:23Z
dc.date.issued2022
dc.date.submitted2022-03-30
dc.date.updated2022-06-14T08:00:22Z
dc.description.abstractForces and mechanical properties of cells and tissues set constraints on biological functions, and are key determinants of human physiology. Changes in cell mechanics may arise from disease, or directly contribute to pathogenesis. Malaria gives many striking examples. Plasmodium parasites, the causative agents of malaria, are single-celled organisms that cannot survive outside their hosts; thus, thost-pathogen interactions are fundamental for parasite's biological success and to the host response to infection. These interactions are often combinations of biochemical and mechanical factors, but most research focuses on the molecular side. However, Plasmodium infection of human red blood cells leads to changes in their mechanical properties, which has a crucial impact on disease pathogenesis because of the interaction of infected red blood cells with other human tissues through various adhesion mechanisms, which can be probed and modelled with biophysical techniques. Recently, natural polymorphisms affecting red blood cell biomechanics have also been shown to protect human populations, highlighting the potential of understanding biomechanical factors to inform future vaccines and drug development. Here we review biophysical techniques that have revealed new aspects of Plasmodium falciparum invasion of red blood cells and cytoadhesion of infected cells to the host vasculature. These mechanisms occur differently across Plasmodium species and are linked to malaria pathogenesis. We highlight promising techniques from the fields of bioengineering, immunomechanics, and soft matter physics that could be beneficial for studying malaria. Some approaches might also be applied to other phases of the malaria lifecycle and to apicomplexan infections with complex host-pathogen interactions.
dc.identifier.doi10.17863/CAM.85477
dc.identifier.eissn2235-2988
dc.identifier.issn2235-2988
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338068
dc.languageen
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.publisher.urlhttp://dx.doi.org/10.3389/fcimb.2022.908241
dc.subjectPlasmodium
dc.subjectbiophysics
dc.subjectcytoadhesion
dc.subjectimaging
dc.subjectmalaria
dc.subjectmechanobiology
dc.subjectmicrofluidics
dc.subjectErythrocytes
dc.subjectHumans
dc.subjectLife Cycle Stages
dc.subjectMalaria
dc.subjectPlasmodium falciparum
dc.subjectProtozoan Proteins
dc.titleBiophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria.
dc.typeArticle
dcterms.dateAccepted2022-04-27
prism.publicationNameFront Cell Infect Microbiol
prism.volume12
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/R011443/1)
pubs.funder-project-idWellcome Trust (220266/Z/20/Z)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3389/fcimb.2022.908241

Files

Original bundle
Now showing 1 - 3 of 3
No Thumbnail Available
Name:
additional-files.zip
Size:
3.05 MB
Format:
ZIP file
Description:
Supporting information
Licence
http://creativecommons.org/licenses/by/4.0/
Download
Thumbnail Image
Name:
fcimb-12-908241.pdf
Size:
2.48 MB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
http://creativecommons.org/licenses/by/4.0/
Download
No Thumbnail Available
Name:
fcimb-12-908241.xml
Size:
284.65 KB
Format:
Extensible Markup Language
Description:
Bibliographic metadata
Licence
http://creativecommons.org/licenses/by/4.0/
Download

Collections

Jisc Publications Router